Author’s response to reviews Title: The use of an alternate side lying positioning strategy during inhalation therapy does not prolong nebulisation time in adults with Cystic Fibrosis: a randomised crossover trial Authors:
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چکیده
Title: The use of an alternate side lying positioning strategy during inhalation therapy does not prolong nebulisation time in adults with Cystic Fibrosis: a randomised crossover trial Authors: Ruth Dentice ([email protected]) Mark Elkins ([email protected]) Genevieve Dwyer ([email protected]) Peter Bye ([email protected]) Version: 1 Date: 18 Sep 2017 Author’s response to reviews: PULM-D-17-00331 The use of an alternate side lying positioning strategy during inhalation therapy does not prolong nebulisation time in adults with Cystic Fibrosis: a randomised crossover trial Ruth L Dentice; Mark R Elkins; Genevieve M Dwyer; Peter TP Bye BMC Pulmonary Medicine
منابع مشابه
The use of an alternate side lying positioning strategy during inhalation therapy does not prolong nebulisation time in adults with Cystic Fibrosis: a randomised crossover trial
BACKGROUND Inhalation of nebulised medications is performed in upright sitting to maximise lung volumes. The pattern of deposition is poor for inhaled medications in people with Cystic Fibrosis. The pattern tends to be non-uniform and typically the upper lobes receive a reduced dose compared to the rest of the lung. One strategy that has been proposed as having the potential to improve homogene...
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QUESTION Does the timing of inhalation of dornase alpha in relation to physical airway clearance techniques influence the effect of the entire airway clearance regimen?. DESIGN A randomised crossover trial with concealed allocation, intention-to-treat analysis and blinding of patients, therapists, and assessors. PARTICIPANTS Twenty adults with cystic fibrosis who were not taking dornase alp...
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BACKGROUND Reducing nebulisation times for tobramycin solution for inhalation in cystic fibrosis (CF) may improve compliance. METHODS In this single-dose, open-label, two-way crossover study, 13 subjects (7 CF, 6 healthy) were randomised to receive tobramycin via eFlow rapid or LC Plus jet nebuliser. Drug deposition in the lung using gamma scintigraphic imaging, nebulisation times, pharmacoki...
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